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Review: In postmenopausal women and older men, vitamin D plus calcium reduces some fractures

Ann Intern Med. 2014;161(6):JC5. doi:10.7326/0003-4819-161-6-201409160-02005
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Vitamin D should always be combined with calcium to prevent fracture in patients with osteoporosis
Posted on September 22, 2014
Gauranga Dhar
Bangladesh Institute of Family Medicine and Research
Conflict of Interest: None Declared
Traditionally, we, the clinicians use bisphosphonates along with calcium and vitamin D for the treatment of osteoporosis. All the forms of vitamin D; D2, D3, 25-(OH)-D transform to its’ active form
1,25-OH)2-D3 (calcitriol) for proper action; absorption of calcium from GI tract and renal tubular calcium reabsorption. This transformation happens as long as 1-alpha-hydroxylase enzyme is active in proximal tubules of the kidney. This study supports our current practice that we should continue to use calcium with vitamin D along with bisphosphonate for the treatment of osteoporosis. In case of renal impairment, vitamin-D in the form of calcitriol is indicated to prevent fracture from renal osteodystrophy.
Very good alert is seen in this study that Vitamin-D only is not effective in reducing fracture.
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