Critical care is a “team sport.” Effective preparation for the possibility of caring for a critically ill patient with Ebola requires the development of a multidisciplinary team that includes hospital administrators, infectious diseases specialists, hospital epidemiology, occupational medicine providers, biosafety managers, nurses, critical care physicians, respiratory therapists, laboratory staff, and housekeeping. The NIH multidisciplinary team reviewed the personnel required to provide critical care–level support for a seriously ill patient with Ebola for 1 week and derived the following minimum staffing numbers for nurses and physicians: 2 nurses per 8-hour shift (6 per day, or 12 full-time employees), 1 to 2 physicians per shift (3 to 4 per day, or 6 full-time employees), and 1 PPE adherence monitor (called the “Watsan,” 3 per day, or 6 full-time employees). Additional staff needs include respiratory therapists; isolation adherence monitors; cohorted laboratory and housekeeping personnel; and administrative staff to manage logistics, supplies, waste, and public relations. Devoting such resources to patients with Ebola is likely to affect the institution's ability to staff other services. Institutions should also determine ahead of time whether they will require staff to care for patients with Ebola or if they will rely on health care providers who volunteer (we chose volunteers).