The full content of Annals is available to subscribers

Subscribe/Learn More  >
ACP Journal Club |

Spironolactone did not reduce cardiac outcomes in symptomatic heart failure with preserved ejection fraction

Ann Intern Med. 2014;161(8):JC6. doi:10.7326/0003-4819-161-8-201410210-02006
Text Size: A A A





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Heart failure patients with preserved ejection fraction should avoid spironolatone
Posted on October 21, 2014
Gauranga Dhar
Bangladesh Institute of Family Medicine and Research
Conflict of Interest: None Declared
The Randomized Aldactone Evaluation Study (RALES) and some other studies proved that addition of spironolactone to standard therapy in patients with heart failure with reduced ejection fraction reduces all cause mortality but study on the effect of this mineralocorticoid antagonist in heart failure patients with preserved ejection fraction is sparse.
Treatment of Preserved Cardiac Function Heart failure with an Aldosterone Antagonist (TOPCAT) trial probably the largest trial with patients with heart failure with preserved ejection fraction of at least 45%.
In light of TOPCAT trial, we the physicians should modify the treatment strategy in this population.
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.