In this issue, Navarese and colleagues (5) report the results of a meta-analysis of study-level data from 24 randomized trials that evaluated the effects of PCSK9 antibodies in 10 159 adults with hypercholesterolemia. Most trials involved patients treated with statins who had not met target LDL cholesterol goals, although some focused only on patients who did not tolerate statins. Summary trial data showed that, compared with placebo or ezetimibe control groups, PCSK9 inhibition led to a 47% reduction in LDL cholesterol and a 26% reduction in lipoprotein(a) levels. Data also showed reductions in all-cause mortality rates, cardiovascular mortality rates, and myocardial infarctions, all of which were statistically significant except the cardiovascular mortality outcome (P = 0.084). These results were robust in sensitivity analyses that were stratified by intensity of background statin therapy or by comparator (placebo or ezetimibe). Serious adverse events occurred in approximately 9% and 8% of PCSK9 and comparator groups, respectively. The summary estimates did not include recent results of the Open-Label Study of Long-Term Evaluation Against LDL Cholesterol (OSLER) trials 1 and 2, which studied evolocumab; composite findings of those 2 trials showed a statistically significant reduction in a combined cardiovascular end point with evolocumab (6).