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ACP Journal Club |

Incretin use was not associated with increased risk for acute pancreatitis

Ann Intern Med. 2015;162(12):JC12. doi:10.7326/ACPJC-2015-162-12-012
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More population based studies are required to prove that incretin based therapy is safe in regard of pancreatitis.
Posted on June 24, 2015
Gauranga Dhar
Bangladesh Institute of Family Medicine and Research
Conflict of Interest: None Declared
There are two types of incretin based anti-hyperglycemic agents; GLP-1 agonists and DPP-IV inhibitors.
In a study published in “Gastroenterology” where researchers found that exenatide (a GLP-1 agonist) users are at increased risk of pancreatitis. Researches in both human and animal models found the same result.
A recent Novo-Nordisk-sponsored trial on liraglutide, a GLP-1 agonist (phase 2 and 3; NN2211 identifiers) published in June-2015 issue of Diabetes Care found that liraglutide users are associated with increased incidences of both acute and chronic pancreatitis in comparison to glimepiride users.
Since introduction of sitagliptin in 2006 several reports of acute pancreatitis (with some cases of necrotizing pancreatitis) were submitted to the FDA.
Although cohort was large and population based, current study is confined to a specific geographical area.
More large scale multi-racial studies are required to prove the safety of incretin based therapy in regard of pancreatitis.
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