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In Chinese adults with hypertension, adding folic acid to enalapril reduced incident stroke

Ann Intern Med. 2015;163(2):JC8. doi:10.7326/ACPJC-2015-163-2-008
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Why not to prescribe folic acid to high risk patients associated with endothelial dysfunction?
Posted on August 10, 2015
Gauranga Dhar
Bangladesh Institute of Family Medicine and Research
Conflict of Interest: None Declared
Still there is debate that reduction of serum homocystein by folic acid reduces cardiovascular events but it is already an established fact that hyperhomocysteinemia leads to increased endothelial injury and release of pro-inflammatory cytokines causing increased risk of cardiovascular events. This study was conducted in patients with hypertension who already suffer from endothelial dysfunction. No guideline still suggests screening of serum folate but as a result of this study I think folic acid supplementation may be prescribed to patients associated with endothelial dysfunction.
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