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Editorials |

Placebos for Knee Osteoarthritis: Reaffirmation of “Needle Is Better Than Pill”Placebos for Knee OA: Reaffirmation of “Needle Is Better Than Pill”

Weiya Zhang, PhD; Kun Zou, PhD; and Michael Doherty, MA, MD
[+] Article, Author, and Disclosure Information

This article was published online first at www.annals.org on 28 July 2015.


From School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1580.

Requests for Single Reprints: Michael Doherty, MA, MD, Academic Rheumatology, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom; e-mail, michael.doherty@nottingham.ac.uk.

Current Author Addresses: Professors Zhang and Doherty and Dr. Zou: Academic Rheumatology, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom.


Ann Intern Med. 2015;163(5):392-393. doi:10.7326/M15-1580
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In this issue, Bannuru and colleagues' network metaanalysis examines the relative efficacy of different placebos given for knee osteoarthritis. The editorialists discuss how patient expectancy and contextual factors influence the placebo effect. They believe that randomized, placebo-controlled trial reports need to better recognize and account for placebo effects when comparing interventions.

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