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The ADAPTABLE Trial and PCORnet: Shining Light on a New Research ParadigmThe ADAPTABLE Trial and PCORnet

Adrian F. Hernandez, MD, MHS; Rachael L. Fleurence, PhD; and Russell L. Rothman, MD, MPP
[+] Article, Author, and Disclosure Information

This article was published online first at www.annals.org on 25 August 2015.

From Duke Clinical Research Institute, Durham, North Carolina; Patient-Centered Outcomes Research Institute, Washington, DC; and Vanderbilt University, Nashville, Tennessee.

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1460.

Requests for Single Reprints: Adrian F. Hernandez, MD, MHS, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715; e-mail, adrian.hernandez@duke.edu.

Current Author Addresses: Dr. Hernandez: Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715.

Dr. Fleurence: Patient-Centered Outcomes Research Institute, 1828 L Street, Washington, DC 20036.

Dr. Rothman: Vanderbilt Center for Health Services Research, Vanderbilt University Medical Center, Suite 6000, Medical Center East, Nashville, TN 37232-8300.

Author Contributions: Conception and design: A.F. Hernandez, R.L. Fleurence, R.L. Rothman.

Drafting of the article: A.F. Hernandez, R.L. Fleurence, R.L. Rothman.

Critical revision of the article for important intellectual content: R.L. Fleurence, R.L. Rothman.

Final approval of the article: A.F. Hernandez, R.L. Fleurence, R.L. Rothman.

Ann Intern Med. 2015;163(8):635-636. doi:10.7326/M15-1460
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This commentary discusses the National Patient-Centered Clinical Research Network (PCORnet), a “network of networks” to facilitate research that addresses important clinical questions, and the first trial (ADAPTABLE) under the network.

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