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Editorials |

The Predicament of Comparative Effectiveness Research Using Observational DataComparative Effectiveness Research With Observational Data

Jeptha P. Curtis, MD; and Harlan M. Krumholz, MD, SM
[+] Article, Author, and Disclosure Information

This article was published online first at www.annals.org on 27 October 2015.

From Yale School of Medicine, New Haven, Connecticut.

Grant Support: Drs. Curtis and Krumholz are supported by grant U01 HL105270-05 (Center for Cardiovascular Outcomes Research at Yale University) from the National Heart, Lung, and Blood Institute.

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-2490.

Requests for Single Reprints: Harlan M. Krumholz, MD, SM, Yale School of Medicine, 1 Church Street, Suite 200, New Haven, CT 06510; e-mail, harlan.krumholz@yale.edu.

Current Author Addresses: Dr. Curtis: Yale School of Medicine, PO Box 208017, 333 Cedar Street, New Haven, CT 06520-8017.

Dr. Krumholz: Yale School of Medicine, 1 Church Street, Suite 200, New Haven, CT 06510.

Ann Intern Med. 2015;163(10):799-800. doi:10.7326/M15-2490
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In this issue, Hansen and colleagues' observational study compared outcomes for patients who had early versus conservative invasive treatment for acute coronary syndromes. The editorialists discuss whether comparative effectiveness research using observational data can be strong enough to influence practice.

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