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The Effect of Controlled Drinking in Alcoholic Cardiomyopathy

Josep María Nicolás, MD; Joaquim Fernández-Solà, MD; Ramon Estruch, MD; Joan Carles Paré, MD; Emilio Sacanella, MD; Alvaro Urbano-Márquez, MD; and Emanuel Rubin, MD
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From Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; and Jefferson Medical College, Philadelphia, Pennsylvania.

Grant Support: By grants from Fondo de Investigaciones Sanitarias (FIS 98/0330 and 99/0115) and by Generalitat de Catalunya (CUIR 1999/SGR-279).

Requests for Single Reprints: Emanuel Rubin, MD, Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, 1020 Locust Street, Suite 279, Philadelphia, PA 19107.

Current Author Addresses: Drs. Nicolás, Fernández-Solà, Estruch, Paré, Sacanella, and Urbano-Márquez: Hospital Clinic, Villarroel, 170, Barcelona, Spain 08036.

Dr. Rubin: Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, 1020 Locust Street, Suite 279, Philadelphia, PA 19107.

Author Contributions: Conception and design: J.M. Nicolás, J. Fernández-Solà, A. Urbano-Márquez, E. Rubin.

Analysis and interpretation of the data: J.M. Nicolás, J. Fernández-Solà, J.C. Paré, E. Rubin.

Drafting of the article: J.M. Nicolás, J. Fernández-Solà, E. Rubin.

Critical revision of the article for important intellectual content: D. Estruch, E. Rubin.

Final approval of the article: A. Urbano-Márquez, E. Rubin.

Provision of study materials or patients: J. Fernández-Solà, D. Estruch, E. Sacanella.

Statistical expertise: J.M. Nicolás.

Obtaining of funding: J.M. Nicolás, J. Fernández-Solà.

Administrative, technical, or logistic support: J.M. Nicolás, A. Urbano-Márquez.

Collection and assembly of data: J. Fernández-Solà, D. Estruch, J.C. Paré, E. Sacanella.

Ann Intern Med. 2002;136(3):192-200. doi:10.7326/0003-4819-136-3-200202050-00007
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Alcoholic cardiomyopathy is a complication of long-standing alcohol abuse and is related to a person's total lifetime dose of ethanol (12). The malady is not uncommon; in developed countries, it accounts for 3% to 40% of all cases of dilated cardiomyopathy (36). In our previous studies, one third of asymptomatic alcoholic persons showed some evidence of cardiac dysfunction (12, 7). Although the natural course of chronic alcoholic cardiomyopathy is not precisely defined, abstinence from alcohol has been reported to improve cardiac function, or at least halt its deterioration (810).

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Changes in left ventricular ejection fraction in patients with alcoholic cardiomyopathy, according to daily ethanol intake during the first year of the study.squares

Group values ( ) are expressed as means; error bars represent 95% CIs.

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Summary for Patients

Drinking Less Alcohol Improves Heart Function in People with Alcohol-Related Heart Failure

The summary below is from the full report titled “The Effect of Controlled Drinking in Alcoholic Cardiomyopathy.” It is in the 5 February 2002 issue of Annals of Internal Medicine (volume 136, pages 192-200). The authors are JM Nicolás, J Fernández-Solà, R Estruch, JC Paré, E Sacanella, A Urbano-Márquez, and E Rubin.


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