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Gene Therapy in Humans: A New Era Begins

William N. Kelley, MD
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Requests for Reprints: William N. Kelley, MD, 21 Penn Tower, 34th and Civic Center Boulevard, Philadelphia, PA 19104-6055.

University of Pennsylvania Medical Center
Philadelphia, PA 19104

Ann Intern Med. 1991;114(8):697-698. doi:10.7326/0003-4819-114-8-697
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Remarkable advances have occurred in the field of molecular biology in the last 30 years. Our understanding of pathophysiologic processes and their relationship to gene structure, function, and control has grown impressively. Indeed, the new biology has matured to the point where its applications to the practice of medicine are increasingly apparent. Recombinant technology is now used not only for diagnostic purposes but also for the generation of naturally occurring biologic products that are currently available for patient care. For the last decade, increasing attention has focused on the possibility that genes could be inserted into somatic cells to correct



gene therapy

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