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Effects of Folic Acid Supplementation on Hearing in Older Adults: A Randomized, Controlled Trial

Jane Durga, PhD; Petra Verhoef, PhD; Lucien J.C. Anteunis, PhD; Evert Schouten, PhD; and Frans J. Kok, PhD
[+] Article, Author, and Disclosure Information

From Wageningen University and Wageningen Centre for Food Sciences, Wageningen, the Netherlands, and University Hospital Maastricht, Maastricht, the Netherlands.

Acknowledgments: The authors thank all study participants for their time and motivation; the Folic Acid and Carotid Intima-media Thickness (FACIT) trial research team for their dedication and enthusiasm; Mickey Chenault, University Hospital Maastricht and Heinsius Houbolt Foundation, for data verification; and Martijn Katan, Wageningen University and Wageningen Centre for Food Sciences, for critical comments on the manuscript.

Grant Support: By the Netherlands Organisation for Health Research and Development (ZonMw, grant no. 20010002), Wageningen University, and Wageningen Centre for Food Sciences.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Jane Durga, PhD, Cognitive Sciences Group, Nutrition & Health Department, Nestlé Research Center, PO Box 44, CH-1000 Lausanne 26, Switzerland; e-mail, jane.durga@rdls.nestle.com.

Current Author Addresses: Dr. Durga: Cognitive Sciences Group, Nutrition & Health Department, Nestlé Research Center, PO Box 44, CH-1000 Lausanne 26, Switzerland.

Dr. Verhoef: Nutrition Department, Unilever–UFHRI, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands.

Dr. Anteunis: Department of Otorhinolaryngology, Division of Audiology, Brain, and Behavior Institute, University Hospital Maastricht, 6200 MD Maastricht, The Netherlands.

Dr. Schouten: Food and Consumer Product Safety Authority, PO Box 19506, 2500 CM The Hague, The Netherlands.

Dr. Kok: Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands.

Author Contributions: Conception and design: J. Durga, L.J.C. Anteunis, E. Schouten.

Analysis and interpretation of the data: J. Durga, L.J.C. Anteunis, E. Schouten.

Drafting of the article: J. Durga, L.J.C. Anteunis, E. Schouten.

Critical revision of the article for important intellectual content: J. Durga, P. Verhoef, L.J.C. Anteunis, F.J. Kok.

Final approval of the article: J. Durga, P. Verhoef, L.J.C. Anteunis, E. Schouten, F.J. Kok.

Provision of study materials or patients: J. Durga.

Statistical expertise: J. Durga.

Obtaining of funding: J. Durga, P. Verhoef, E. Schouten, F.J. Kok.

Administrative, technical, or logistic support: J. Durga, P. Verhoef.

Collection and assembly of data: J. Durga, E. Schouten.

Ann Intern Med. 2007;146(1):1-9. doi:10.7326/0003-4819-146-1-200701020-00003
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The Figure shows the flow of the participants through the trial. Sixteen participants (2%) did not return for the audiometric assessment after 3 years, and 5 participants stopped treatment prematurely. The proportion of these participants did not differ between the groups (P = 0.178). Except for these participants, adherence was high (99% of the capsules were reportedly consumed). The lowest reported average adherence over a 12-week period was consumption of 87% of the capsules.

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Grahic Jump Location
Study flow diagram.

The flowchart shows the flow of participants through the recruitment phases (November 1999 to April 2001) and the study (September 2000 to December 2004). *Participants may have been excluded for several reasons.

Grahic Jump Location




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Summary for Patients

The Effect of Folic Acid on Hearing in Older Adults

The summary below is from the full report titled “Effects of Folic Acid Supplementation on Hearing in Older Adults. A Randomized, Controlled Trial.” It is in the 2 January 2007 issue of Annals of Internal Medicine (volume 146, pages 1-9). The authors are J. Durga, P. Verhoef, L.J.C. Anteunis, E. Schouten, and F.J. Kok.


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