If you are like many practicing physicians, you probably have a stack of unread journals accumulating dust somewhere in your home or office. You have not tossed them in the recycle bin yet because you remain optimistic that someday you will have a few free minutes to look through them. You also have this nagging sense that there probably is something buried in the stack that you should know. As editors, we would like to believe that our readers rush to read every issue of Annals of Internal Medicine from cover to cover. As clinicians, we know that the realities of practice and life make that unlikely. We also know that, when practicing physicians do get to their journals, they too often find the content irrelevant or, at best, tangential to their daily work of caring for patients. In this issue of Annals, we launch a new section, “In the Clinic,” to better connect Annals to clinical practice.