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Trials That Matter: Minimizing Treatment of Mild, Persistent Asthma

Michael A. Grippi, MD; and Cynthia Mulrow, MD, MSc, Deputy Editor
[+] Article, Author, and Disclosure Information

From the Hospital of the University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19004, and American College of Physicians, Philadelphia, PA 19106.

Potential Financial Conflicts of Interest: Honoraria: M.A. Grippi (InterMune Corporation).

Requests for Single Reprints: Customer Service, American College of Physicians, 190 N. Independence Mall West, Philadelphia, PA 19106-1572.

Current Author Addresses: Dr. Grippi: Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104.

Dr. Mulrow: American College of Physicians, 190 N. Independence Mall West, Philadelphia, PA 19106-1572.

Ann Intern Med. 2007;147(5):344-345. doi:10.7326/0003-4819-147-5-200709040-00011
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Current guidelines for management of mild, persistent asthma recommend inhaled corticosteroids as first-line therapy (13). Long-term use of these agents in high doses may cause various adverse effects. Therefore, patients may inquire about, and clinicians should consider, alternative management strategies, including low-dose, once-daily inhaled corticosteroids and oral regimens that do not use corticosteroids. Two recently published trials address such approaches (45).



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