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Benzodiazepines and Hip Fractures

Gerson T. Lesser, MD
[+] Article and Author Information

From Mount Sinai School of Medicine and the Jewish Home and Hospital, New York, NY 10029.


Potential Financial Conflicts of Interest: None disclosed.


Ann Intern Med. 2007;147(5):347-348. doi:10.7326/0003-4819-147-5-200709040-00016
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Why prefer the larger problem?
Posted on April 13, 2008
Jonathan P. Krueger
No Affiliation
Conflict of Interest: None Declared

The time required for a condition to not influence a subsequent conditions is certainly a problem for any within-participants design. However solutions include randomizing order of exposure to conditions, adding time of no treatment between conditions (a useful additional control in any case), and seeking guidance on how long influences persist from condition to condition.

Is it preferable to face a larger problem: higher variability, lower noise, lower power, and being unable to conclude whether the treatment reliably affects some subjects, separate from the overall effect?

Certainly it's true that menopausal symptoms change through time. That however is a stronger argument for within-participant designs, since when each participant is her own control, her symptom variability is not mixed with the other participants'.

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