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Sequential Therapy for Helicobacter pylori: A Worthwhile Effort for Your Patients

Barry Marshall, MD
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Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Barry Marshall, MD, The University of Western Australia, School of Biomedical, Biomolecular, and Chemical Sciences, Microbiology & Immunology, H. pylori Laboratory, Room 2.13 L Block, Queen Elizabeth II Medical Centre, Nedlands 6009, Australia.

From The University of Western Australia, School of Biomedical, Biomolecular, and Chemical Sciences, Microbiology & Immunology, H. pylori Laboratory, Nedlands 6009, Australia.

Ann Intern Med. 2008;148(12):962-963. doi:10.7326/0003-4819-148-12-200806170-00227
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In sequential therapy for H. pylori, more antibiotics are added to the treatment regimen in sequence rather than giving all 4 drugs together. In this issue, Jafri and colleagues' meta-analysis of clinical trials of sequential therapy convincingly confirms the efficacy of sequential therapy for H. pylori. Marshall describes several reasons why this therapeutic strategy makes sense.

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