The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

A Linoleate-enriched Cheese Product Reduces Low-Density Lipoprotein in Moderately Hypercholesterolemic Adults

Paul A. Davis, PhD; Jean-Francois Platon, PhD; M. Eric Gershwin, MD; Georges M. Halpern, MD; Carl L. Keen, PhD; Donna DiPaolo, MS; Janet Alexander, BS; and Vincent A. Ziboh, PhD
[+] Article, Author, and Disclosure Information

From the University of California at Davis, Davis, California; Actiotech, Paris, France. Requests for Reprints: Paul A. Davis, PhD, Department of Internal Medicine, TB156, University of California at Davis, Davis, CA 95616. Acknowledgments: The authors thank Rita Tezanos-Pinto, MT, and the Lipid Assay Laboratory staff for their assistance in analyzing the lipoprotein samples; Drs. Stephen Phinney and Anna Tang of the University of California, Davis, CNRU Lipid Metabolism Core Unit for the fatty-acid analysis of the modified-fat cheese product; and Christine Trapp for her expert handling of the study participants with respect to dietary surveys, cheese distribution, and compliance follow-up. Grant Support: In part by University of California, Davis, National Institutes of Health Clinical Nutrition Research Unit (DK 35747) and Sorrento Cheese Company, Buffalo, New York.

Copyright 2004 by the American College of Physicians

Ann Intern Med. 1993;119(7_Part_1):555-559. doi:10.7326/0003-4819-119-7_Part_1-199310010-00002
Text Size: A A A

Objective: To test the effect of substituting a modified-fat cheese product into the diets of hypercholesterolemic adults.

Design: A 4-month, randomized, double-blind, crossover substitution trial.

Setting: General community outpatient study.

Participants: Twenty-six healthy adult volunteers (17 men, 9 women) with moderate hypercholesterolemia (total cholesterol >5.69 mmol/L but < 7.24 mmol/L).

Intervention: Daily substitution of 100 g of cheese, either partial skim-milk mozzarella or modified-fat (vegetable oil) mozzarella cheese product, into participants' normal diets. Participants consumed an assigned cheese for 2 months, at which time they crossed over to consume the other study cheese.

Main Outcome Measures: Plasma lipid and apolipoprotein levels were measured at baseline and at 2 and 4 months after initiation of the study. Compliance was assessed by body weight and by biweekly dietary records and interviews.

Results: No differences in weight or in the amount or type of calories consumed were found during the study. No statistically significant changes in lipid values resulted from consumption of mozzarella cheese. Modified-fat cheese substitution resulted in a decreased low-density lipoprotein cholesterol level when compared with levels at both baseline ( 0.28 mmol/L; 95% CI, 0.14 to 0.42 mmol/L) and during consumption of the skim-milk mozzarella cheese ( 0.38 mmol/L; 95% CI, 0.2 to 0.70 mmol/L). Findings for total cholesterol were similar. High-density lipoprotein cholesterol, plasma triglyceride, and apolipoprotein A-I and B-100 levels were unaltered. Both sexes responded similarly.

Conclusions: A linoleate-enriched cheese product, in the absence of any other changes in diet or habits, substituted into the normal diets of hypercholesterolemic adults reduced low-density lipoprotein and plasma cholesterol levels.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.