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Scarlatinal Nephritis Experimentally Induced in the Dog.

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DUVAL CHARLES W., HIBBARD R. J..  (Proc. Soc. for Exper. Biol. and Med.. , June, 1927; , page 876)..


Ann Intern Med. 1927;1(2):115-116. doi:10.7326/0003-4819-1-2-115
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According to these workers the dog is not only highly susceptible to infection with Streptococcus scarlatinae but will develop regularly a severe and often fatal form of acute glomerulonephritis following the injection of the specific streptococcal toxin alone. The animals show no exanthem, but the lesions are regarded as corresponding histopathologically to the glomerular and acute interstitial scarlatinal nephritis of man. Eight young healthy dogs were injected with 5 mils each of filtered streptococcal "lysate" which had been prepared in vivo after the method previously described by the authors. Within 4-6 hours they developed symptoms of toxemia, and 24 hours

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