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The Pathological and Clinical Significance of Congenital One-Sided Kidney Defect, With the Presentation of Three New Cases of Agenesia and One of Aplasia*

CARL H. FORTUNE, M.D.
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Senior Instructor in Pathology in The University of Michigan


Ann Intern Med. 1927;1(6):377-399. doi:10.7326/0003-4819-1-6-377
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Congenital one-sided kidney defect has been reported by many writers, beginning with Aristotle, because it has been considered a rare and interesting structural anomaly. Little attention was paid by the older writers to the clinical significance, probably partly because they considered the condition extremely unusual, and partly because many of the cases occurred in old people dying of other causes. The earlier reports, as well as some of the recent ones, are merely anatomical descriptions, without clinical data or description of other pathology found post-mortem. In the latter part of the nineteenth century with the development of surgery of the

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