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Regeneration of Tubular Epithelium in the Human Kidney Following Injury by Mercuric Chloride

WARREN C. HUNTER, M.A., M.D.
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Paragraph52851*From the Department of Pathology, University of Oregon Medical School, Portland.


Ann Intern Med. 1928;1(7):463-469. doi:10.7326/0003-4819-1-7-463
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It IS rather generally believed that the functional epithelium of the human kidney has only a limited regenerative capacity and that the clinical importance of this is negligible. The matter receives little or no consideration in most systems and textbooks of medicine and pathology. Yet in the voluminous literature on renal diseases are many descriptions of regeneration in the kidney of man and experimental animals, particularly after injury by the salts of heavy metals.

As long ago as 1879 Weigert (1) noted regeneration in the renal parenchyma of animals poisoned with chromic acid. Likewise Thorel (2) (1903) found marked evidence

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