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Evidence Concerning the Effect of Insulin On Carbohydrate Tolerance

Ann Intern Med. 1928;1(8):607-612. doi:10.7326/0003-4819-1-8-607
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Previous to the discovery of insulin the treatment of diabetes mellitus consisted entirely of dietary measures. Various writers outlined methods of procedure which were calculated to maintain a sugar free urine and still keep the patient fairly well nourished. These experiments met with a variable degree of success, depending on the severity of the disease in the patients under their care.

The discovery of insulin changed the treatment of this malady as no treatment has been changed before. The early writings on insulin which appeared shortly after the completion of the experimental work which led to its discovery, give one


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