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A Further Study of Gye's Hypothesis on the Etiology of Malignant Tumors.

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ByKOLMER JOHN A., HARKINS MALCOLM J.. . (The Jour. of Cancer Research. , October, 1927; , p. 217.).

Ann Intern Med. 1928;1(8):628. doi:10.7326/0003-4819-1-8-628
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Nearly two years have elapsed since Gye made his announcement that the cause of all malignant new growths of man and the lower animals is a filterable but cultivatable ultramicroscopic microbe, which, however, is unable to produce tumors unless the resistance of the host is first specifically reduced by a second cellular product or "chemical stimulant" called the "specific factor," so designated because the latter and not the microbe was held by him to determine the kind and species specificity of of tumors. No confirmation of Gye's work has up to the present time been obtained by any worker; indeed




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