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The Active Principle of the Posterior Lobe of the Pituitary Gland. I, The Demonstration of the Presence of Two Active Principles; II, The Separation of the Two Principles and Their Concentration in the Form of Potent Solid Preparations.

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By Kamm Oliver, Aldrich T. B., Grote I. W., Rowe L. W., Brybee E. P..  (Jour, of the Amer. Chem. Soc.. , 50:, 573., 1928.).

Ann Intern Med. 1928;1(11):939-940. doi:10.7326/0003-4819-1-11-939_2
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The manifold physiological activities of extracts of the posterior lobe of the pituitary gland are now well known: namely, their effect in stimulating uterine contractions (oxytocic activity), their ability to raise the blood pressure (pressor activity) and their diuretic-antidiuretic effects (renal activity). These three types of activity have led the way to three definite and important medical applications; these are illustrated respectively by the use of pituitary solutions in obstetrics, in the treatment of surgical shock, and in the control of diabetes insipidus. On the other hand, chemical information concerning the physiologically active constituents of pituitary extracts is rather meager


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