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Emetin—Its Effect on the Rabbit's Heart.

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By BERMAN PHOEBUS, LEAKE WILLIAM H..  (Research Prize Essay of the California Medical Association for 1928. California and Western Medicine. , June, 1928; , Vol. XXVIII..)

Ann Intern Med. 1928;2(3):298. doi:10.7326/0003-4819-2-3-298_1
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Myocardial failure associated with the therapeutic use of emetin is not unknown, and probably occurs more frequently than the reports indicate, as emetin and its salts are widely used in the treatment of amebiasis and other protozoan infections. The literature contains only a few articles dealing with the effects of emetin on the heart. It was thought, therefore, that an electrocardiographic study of the effect of emetin on the rabbit's heart might reveal interesting findings. Such an investigation was carried out, with the following results: In rabbits, emetin hydrochlorid given intravenously in doses between one and two mg. per pound




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