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Studies in Experimental Syphilis. VIII. On the Localization of Syphilitic Lesions in Inflamed Areas.

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By CHESNEY ALAN M.. , M.D., TURNER THOMAS B.. , M.D., and HALLEY CHAS. R.. , M.D. (Bull. of the Johns Hopkins Hospital. , 1928; , XLII:, pp. 319.-334).


Ann Intern Med. 1928;2(4):385. doi:10.7326/0003-4819-2-4-385_1
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These workers present a series of experiments in which rabbits with either healed or granulating wounds (or both) upon their backs were subsequently inoculated intratesticularly or intravenously with a virulent strain of Spirocheta pallida. In each instance syphilitic lesions developed in the scars of the wounds. These lesions exhibited a marked tendency to conform to the pattern of the scars. The incubation period of the lesions developing after intravenous inoculation corresponded closely with that of lesions which develop at the site of inoculation after subcutaneous injection. From this it is inferred that shortly or immediately following intravenous inoculation the spirochetes

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syphilis

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