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Clinical and Pathological Changes in Livers of Copper-fed Animals.

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By Von Glahn William C., Flinn Frederick B..  (Proc. of the Soc. f. Exper. Biol. and Med.. , December, 1928; , p. 200.).

Ann Intern Med. 1929;2(8):835. doi:10.7326/0003-4819-2-8-835
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A study of the chemical and pathological effects of copper on the liver was made on a series of guinea pigs, albino rats and rabbits. Different groups of matured Belgian hares, kept on a standard diet of hay and oats, with cabbage and carrots on alternate days were fed daily doses of various copper salts. In each of the rabbits, yellow or yellowish brown refractile pigment was found in the liver cells. In some, pigment was also present in phagocytes in the portal areas and occasionally in connective tissue cells in the same region. In a few animals, some of



copper ; liver

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