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The Experimental Transmission of Leukemia in Mice.

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By Richter Maurice N., MacDowell E. C..  (Trans. Soc. for Exper. Biol. and Med.. , February, 1929; , p. 362.).

Ann Intern Med. 1929;2(11):1230. doi:10.7326/0003-4819-2-11-1230_1
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The only report in the literature of the successful transmission of leukemia in mammals is that of Snijders, who succeeded in transmitting the disease by the inoculation of emulsions of tissues from spontaneously affected guinea pigs into normal animals of the same species. Unsuccessful attempts to transmit leukemia in mice were made by Haaland and Tyzzer. In a strain of mice designated as C58, which had been inbred by brother-sister matings since 1921, it was observed that a considerable number of those that lived more than 8 months had enlargements of their spleens and lymph nodes, which on microscopic examination



leukemia ; mice

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