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Ann Intern Med. 1929;2(12):1346-1348. doi:10.7326/0003-4819-2-12-1346
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In the higher animals the adrenals consist of two forms of tissue differing widely in their structure, genesis and function, the cortex and the medullary portion. It has been generally accepted that the medulla is the place of production of adrenalin, and that this substance is produced also in other glandular systems closely related to the sympathetic nervous system. But with the acceptance of this fact our knowledge of the general function of the adrenals is exhausted. It would seem logical that the physiology of both tissue complexes must represent an entity corresponding to the anatomical concentration of the two


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