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Studies of Experimental Streptococcus Arthritis. IV. Effect of Sodium Salicylate on Skin Allergy.

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KINSELLA R. A., HAGEBUSH O. E..  (Proc. Soc. f. Exper. Biology and Medicine. , 1929; , XXVI:, p. 857.).

Ann Intern Med. 1929;3(3):287. doi:10.7326/0003-4819-3-3-287_2
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The effect of sodium salicylate on the development of dermal allergy in the presence of hemolytic streptococcal arthritis was studied because this drug is commonly employed in the treatment of acute rheumatic fever, and because the studies of Swift concerning the pathogenesis of this disease support the idea that allergy to streptococcus of various kinds is a factor in its production. As previously reported by these workers, the production of arthritis in rabbits by the inoculation into a knee joint of 0.1 cc. of 24 hr. broth culture of hemolytic streptococcus will be followed in 6 days by the appearance


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