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Dessicated Stomach in the Treatment of Pernicious Anemia

Ann Intern Med. 1929;3(4):386-387. doi:10.7326/0003-4819-3-4-386
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Following Castle's demonstration that the stomach of normal individuals secreted a substance which could develop a blood-maturing principle from meat, Sturgis, Isaacs and Sharp began experiments to determine the nature of the material in the stomach which could produce a hematopoietically active substance. Sharp, on the basis of an original theory, decided that the feeding of stomach should have the same effect on patients with pernicious anemia as liver. A preparation was made by dessicating fresh whole hog stomach and defatting with petroleum benzine, so that 30 gm. of the final material represented 218 gm. of the fresh tissue. This


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