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Brittle Bones And Blue Sclerae. Report Of A Case With Glycosuria

Ann Intern Med. 1930;3(7):700-706. doi:10.7326/0003-4819-3-7-700
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The recognition of the familial occurrence of brittle bones and blue sclerae is credited to Eddowes1, although this association of abnormalities was reported by Spurway2 four years earlier. Later, Bronson3 and Van der Hoeve and de Kleijn4 called attention to the hereditary association of otosclerosis and labyrinthine disease with deafness in the affected families. The syndrome is usually transmitted by the female, though it may be transmitted by the male. A number of affected families has been reported; the articles by Bronson3 and Key5 are accompanied by extensive bibliographies. Since the latter publication, additional families have been studied by Moller6


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