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The Use of Sodium Malate Combinations as a Dietary Substitute for Sodium Chloride.

JOHN C. KRANTZ JR., Ph.D.
Ann Intern Med. 1930;3(8):826-834. doi:10.7326/0003-4819-3-8-826
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Introduction: The prevalence of the prescribing of the diet of salt restriction for patients suffering with chronic interstitial nephritis, edema or hypertension is emphasized by Allen1 who estimates this number to be more than two million in the United States. Although the most enthusiastic advocates of the diet of salt restriction claim beneficial results in cases of nephritis, edema and hypertension, little evidence is available in the literature indicating work upon the production of sodium chloride substitutes to increase the palatability of the salt restricted diet. In 1912 Javal2 suggested the use of sodium bromide or iodide to improve the

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