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Ann Intern Med. 1930;3(9):943-946. doi:10.7326/0003-4819-3-9-943_2
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During the last several years there have appeared in the German literature various articles suggesting that under the modern arsenical treatment of syphilis there is actually taking place an increasing and earlier incidence of the so-called metaluetic processes, such as leucoderma, aortitis, tabes and progressive paralysis, while on the other hand the tertiary skin lesions are less frequently encountered. The clinical face of syphilis seems to have essentially altered. Wilmans first called attention to the apparent increase in paresis and tabes; and although his conclusions have been confirmed by numerous syphilologists, they have been contradicted by nearly as many others.


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