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The Hormone of the Adrenal Cortex.

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By HARTMAN FRANK A., BROWNELL KATHERINE A.. , (Proc. of the Soc. f. Exper. Biol. and Med.. , June, 1930; , p. 938.).

Ann Intern Med. 1930;4(2):193. doi:10.7326/0003-4819-4-2-193_1
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These authors have previously demonstrated that an extract which will definitely prolong the lives and ameliorate the symptoms of adrenalectomized cats can be made from adrenal cortex. They have proposed the name of cortin for this hormone, which is essential to life. Heat (80° C. for 5 minutes) destroys it. It is lost upon repeated precipitation with NaCl. Therefore some other method of concentration must be employed. An extract of any desired concentration can be obtained by extracting the cortex with ethyl ether. After removing the ether in vacuo the residue is extracted with warm 80% alcohol. Chilling precipitates much


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