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Acute Coronary Occlusion A Clinical and Electrocardiographic Study of Twenty Cases

LOUIS H. SIGLER, M.D.
Ann Intern Med. 1931;4(8):969-989. doi:10.7326/0003-4819-4-8-969
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Although the pathologic changes associating embolic, thrombotic and endarteritic occlusion of the coronary arteries have been fully described for many years, the clinical picture resulting from such changes seems to have come into prominence only recently. As late as 1906, Broadbent stated that "there are no characteristic physical signs or symptoms by which thrombosis of the coronary arteries can be diagnosed." Blumer, in the 1915 Edition of Osler and McCrae's "Modern Medicine" stated that the symptoms of this condition are "not very characteristic and it is only rarely that the lesion can be diagnosed during life.......... The diagnosis of coronary

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