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The Use of Cortin in Addison's Disease.

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By HARTMAN FRANK A., AARON A. H., CULP J. E.. . (Endocrinology. , 14::438.-442 (Nov.-Dec.), 1930..)


Ann Intern Med. 1931;4(12):1612. doi:10.7326/0003-4819-4-12-1612_1
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As previously shown by Hartman and his associates, cortin, a substance obtained from the adrenal cortex, enables adrenal-ectomized cats and rats to survive indefinitely. If Addison's disease is due to a deficiency of cortin the injection of this substance should ameliorate the disease. A patient, a man 24 years old, who was apparently moribund, has been kept alive for more than five months by this method. When first seen he was in shock with a pulse pressure of 50/20 mm. He was cold and drowsy, complained that his extremities felt numb, and talked irrationally. Twenty-four hours after admission, 5 cc.

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