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The Etiology of Gall Stones. I. Chemical Factors.

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By SCHOENHEIMER RUDOLPH, HRDINA LEO. . (Proc. Soc. Exp. Biol. and Med.. , 1931; , xxviii:, 944.-945)

Ann Intern Med. 1931;5(4):524. doi:10.7326/0003-4819-5-4-524_1
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The problem of gall stone formation is the problem of the precipitation of cholesterol out of the bile. The question has been investigated as to whether the ability of bile to hold cholesterol in solution might be due to some one or all of the bile acids. It was found that the precipitation of bile acids from human bile by ferric chloride, by lead acetate, or by any other means produces a simultaneous precipitation of cholesterin. The complexes of bile acids and cholesterol are readily soluble in water and may be purified without lessening the cholesterol content. Large amounts of


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