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The Etiology of Gall Stones. III. Bile Salt-Cholesterol Ratio in Human Gall Stone Cases.

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By ANDREWS EDMUND, SCHOENHEIMER RUDOLPH, HRDINA LEO. . (Proc. Soc. Exp. Biol. and Med.. , 1931; , xxviii:, 947.-948.)

Ann Intern Med. 1931;5(4):524. doi:10.7326/0003-4819-5-4-524_3
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The two preceding studies having suggested that cholesterol stones are found in the human gall bladder because there are not enough bile salts present to hold the cholesterol in solution, one would expect to find in human gall bladders with cholesterol stones a lesser quantity of bile salts. Results of analyses confirm this expectation. In a group of operated cases the bile salt-cholesterol ratio was found to average 3.4, and in the mixed bladder bile from 30 examples of cholelithiasis found post-mortem this ratio was 0.6. The control series of Newman on normal human gall bladders gave a bile acid-cholesterol


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