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The Relation of Heredity to the Occurrence of Spontaneous Leukemia, Pseudoleukemia, Lymphosarcoma and Allied Diseases in Mice; Preliminary Report.

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By SLYE MAUD. . (Am. Jr. of Cancer. , 1931; , xv:, 1361.-1385).


Ann Intern Med. 1931;5(4):525. doi:10.7326/0003-4819-5-4-525_2
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The familial occurrence of human leukemia and of the related lymphatic diseases has been noted repeatedly. While the data in each individual report are few, they are all in agreement in indicating that in man the leukemic diseases have an hereditary basis and tend to run in families; and, further, that they tend to occur in cancer strains. Dr. Slye found 975 examples of the leukemic diseases in the first 50,000 mice autopsied by her. The division between the sexes was practically equal. All instances of leukemia, pseudoleukemia, and lymphosarcoma were in families carrying other forms of malignancy. All occurrences

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