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Extensive Atrophy of Subcutaneous Fat Following the Repeated Injections of Insulin.

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By WILLIAMS JOHN R.. , M.D., F.A.C.P. (Jr. Lab. and Clin. Med.. , 1931; , xvi:, 1911.-1197.)

Ann Intern Med. 1931;5(5):664. doi:10.7326/0003-4819-5-5-664_2
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That it is important for the patient self-administering insulin to vary the site of the injection, and equally important for the physician to make occasional physical inspections of the regions used, is shown by the increasing group of cases in which local atrophy of the subcutaneous fat occurs. The author reports and illustrates such a case. A woman, aged forty-four years, who had been taking two doses of insulin daily for nearly three years remarked upon the hollows in her thighs. Examination revealed a marked atrophy of the subcutaneous fat on the anterior surfaces of both thighs. The atrophic areas


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