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The Elimination of Phenolsulphonphthalein by the Kidney: The Influence of Pathologic Changes in the Liver.

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By HANNER J. P.. , M.D., and WHIPPLE G. H.. , M.D., Rochester, N. Y. (Arch. Int. Med.. , 1931; , xlviii:, 598.-610.)


Ann Intern Med. 1931;5(6):807-808. doi:10.7326/0003-4819-5-6-807_2
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For many years it has been known that an unusually high degree of renal elimination of phenolsulphonphthalein occurs in certain cases of toxemia of pregnancy. It was suspected that these cases were complicated by some abnormality of the liver. This question has been investigated by carefully controlled experiments in which liver injury has been produced in dogs by various means, and also by the determination of the mode of excretion in animals with complete obstruction of the common bile duct. It was found that the normal dog excretes from about 10 to 15 per cent of the usual dose of

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