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The Effect of Cortin in Asthenia.

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By HARTMAN FRANK A., THORN GEORGE W.. . (Proc. Soc. for Exp. Biol. and Med.. , 1931; , xxix:, 48.-50.)

Ann Intern Med. 1931;5(6):808-809. doi:10.7326/0003-4819-5-6-808_3
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The effect of cortin in the asthenia of a number of clinical conditions including Addison's disease has been investigated. Since increased susceptibility to fatigue is more significant in such conditions than the actual dynamic power of the muscle, a finger ergometer was used to test the threshold of fatigue. Four normal individuals showed a maximum increase in power to do work before the development of fatigue of from 50 to 500 per cent. The effect of cortin on the fatigue point was studied in six cases of Addison's disease, two in which the cortical insufficiency was almost absolute and four




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