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Fatal Cinchophen Poisoning: Report of Six Cases

LAWRENCE PARSONS, M. D.; and WARREN G. HARDING 2ND, M.D., L.R.C.P. and S. (Edin.)
Ann Intern Med. 1932;6(4):514-517. doi:10.7326/0003-4819-6-4-514
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In a previous article we1 reported four fatalities from the use of cinchophen. Three of the patients had been under a mail order treatment for chronic arthritis. All four cases exhibited subacute hepatic degeneration ("yellow atrophy"). Eleven similar cases studied at necropsy by others, presented analogous changes. Several cases subsequently reported, together with others that were overlooked in the preparation of the previous report, increase the total number of fatalities in the literature to thirty-two.1-20 Of this number twenty-six have been autopsied. In all of these cases the essential pathological changes were limited to the liver. Recently we have observed

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poisoning

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