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A Further Study of a White Family Showing Elliptical Erythrocytes

Ann Intern Med. 1932;6(6):775-781. doi:10.7326/0003-4819-6-6-775
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Although it is not uncommon to encounter occasional oval, elliptical or even rod-like erythrocytes in blood smears from perfectly healthy persons, a predominance of such forms in the absence of severe anemia is exceptional.

Two interesting and curious morphological abnormalities involving the erythrocytes may occur in healthy individuals; first, so-called sickle cell anemia which has never been found except in persons of negro extraction and second, a condition characterized by the predominance of elliptical or oval red blood cells and occurring in both whites and negroes. Of the two, sickle cell anemia is by far the more common, the incidence being




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