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Chronic Invalidism with Marked Personality Changes Due to Myxedema

Ann Intern Med. 1932;6(6):806-814. doi:10.7326/0003-4819-6-6-806
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The clinical aspect of myxedema was presented with such thoroughness by the special committee of the Clinical Society of London appointed in 1883 to study this disease that little if anything has been added to the clinical picture since that time. Among the 109 cases reviewed, it was found that slowness of thought and mental disorders of an irritable and suspicious character, with hebetude alternating with somnolence, were very common. Delusions and hallucinations occurred in one-half the cases and insanity was noted in about the same per cent. Acute or chronic mania and dementia were common with a marked predominance


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