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The Clinical Significance of Leucopenia with Special Reference to Idiopathic Neutropenia

STACY R. METTIER, M.D., F.A.C.P.; and HARVEY T. OLSAN, M.D.
Ann Intern Med. 1933;6(7):855-868. doi:10.7326/0003-4819-6-7-855
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The development of leucopenia without apparent cause in a previously healthy individual is a subject about which there has been considerable discussion in recent years. Leucopenia brought on by definite etiologic factors such as certain bacterial and protozoan infections, toxic chemicals, or destruction of the bone marrow by tumor processes is readily understandable. Here the problem is concerned chiefly with diagnosis, and eradication or alleviation of the primary cause. There are instances of leucopenia, however, that are not so readily explained, and in which the cause remains obscure. In the medical literature one may find such conditions designated as "granulopenia",

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