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A Clinical Study of the Graves' Constitution and Its Relation to Thyroid Disease

CARL H. FORTUNE, A.B., M.D.
Ann Intern Med. 1933;6(7):869-876. doi:10.7326/0003-4819-6-7-869
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It is not the purpose of this paper to discuss the relative merits of existing conceptions of thyroid disease, nor to add to such theories; but to present certain data—gathered and interpreted by the clinician—bearing on the constitutional background of hyperthyroidism as expounded by Warthin. From time to time mention has been made of the frequent association between thymic enlargement and thyroid disease, but Warthin's address entitled "The Constitutional Entity of Exophthalmic Goiter and So-Called Toxic Adenoma"1 is the most comprehensive statement of the significance of this association and has given rise to the phrase "Graves' Constitution (Warthin)" which has

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