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The Hematopoietic Response in Pernicious Anemia Following the Intramuscular Injection of Gastric Juice.

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By MORRIS ROGER S.. , M.D.; SCHIFF LEON. , M.D., BURGER GEORGE. , M.D., and SHERMAN JAMES E.. , M.D. (Am. Jr. Med. Sc.. , 1932; , clxxxiv:, 778.-782.)

Ann Intern Med. 1933;6(7):961. doi:10.7326/0003-4819-6-7-961_1
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The results of previous researches have seemed to indicate that the normal stomach secretes a substance (probably the same as that which Castle has shown to be present) which, while without effect on the reticulocytes when administered orally, might cause a response if it could be administered parenterally. This assumption has been tested by the intramuscular injection of neutralized sterile gastric juice and also of a concentrate of normal human gastric juice obtained by evaporation in vacuo. The results prove the presence in normal gastric juice of a powerful bone marrow stimulant, producing not only a marked and very rapid


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