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Ann Intern Med. 1936;10(5):702-704. doi:10.7326/0003-4819-10-5-702
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In 1932, Cushing1 published an account of the syndrome which now goes by his name and which he called pituitary basophilism. As is well known, he was able to collect a group of cases associated with basophilic tumors of the hypophysis, all of which showed some or many of the following characteristics: adiposity of the face, neck, and trunk, the extremities not being affected; vascular hypertension; hirsuties, particularly of the face and trunk in females; impotence or amenorrhea; cyanosis and edema of the extremities; a tendency to polycythemia, with a florid or plethoric complexion; dryness of the skin, often with


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