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Ann Intern Med. 1939;12(11):1896-1899. doi:10.7326/0003-4819-12-11-1896
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Until 1932, investigators of diseases of the pancreas used the concentration of that fat-splitting enzyme in the serum which is capable of splitting simple esters (esterase) in the diagnosis of pancreatic disease; but the results were too variable to be of great value. In 1932, Cherry and Crandall1 reexamined the problem of fat-splitting enzymes in the serum, finding that the activity of the esterase as measured by hydrolysis of ethyl butyrate or tributyrin was affected in one of three ways: it was increased, decreased, or was not changed following experimental ligation of the pancreatic duct of dogs. They therefore concluded


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